Air infiltration through air tight building envelope in biosafety laboratories

Presents the demand of biosafety level-4 laboratories on air tightness of the building envelope. Establishes an air infiltration equation and a pressure decay equation. Tests the leakage at different pressures in a micro environmental laboratory using the constant pressure method. Obtains the values of flow coefficient (a) and flow exponent (b) by fitting, b is close to 1, which is very different with normal cleanrooms. Compares the numerical simulation result of pressure decay with the measured result, and they are in good agreement. Presents some sealing measures for laboratories.